叶文博 博士
Wenbo Ye, Ph.D.
职务:特聘副研究员
研究所:生物医药研究所
研究方向:
生物材料、生物质纳米纤维材料、药物递送载体、纳米制剂
邮箱:wenboye@zjut.edu.cn
个人简介
叶文博（1992−），工学博士，安徽安庆人。
2014年本科毕业于南京林业大学化学工程学院，生物工程专业，获工学学士学位；
2016年硕士毕业于南京林业大学化学工程学院，生物工程领域工程专业，获工学硕士学位；
2018.09−2019.11赴日本九州大学（Kyushu University）进行访问学习，师从生物资源环境科学府（Biomacromolecular materials & Biomaterial design Lab）Tetsuo Kondo教授；
2020年博士毕业于南京林业大学化学工程学院，林产化学加工工程专业，获工学博士学位；
2020.07−2022.08在浙江工业大学化学工程与技术流动站（生物工程学院）从事博士后工作；
2022年8月全职加入浙江大学衢州研究院、生物医药研究所、长江特聘教授张治国博士团队，担任特聘副研究员。
学术成果
叶文博博士多年来一直从事有关于生物材料、生物质纳米纤维材料、药物递送纳米载体和纳米制剂方面的研究。相关研究成果在Green Chem.、Carbohydr. Polym.、ACS Sustain. Chem. Eng.、Int. J. Biol. Macromol.、Biomacromolecules、Cellulose等期刊发表论文16余篇，授权发明专利2项，申请发明专利6项。多次参加国际国内学术会议并作口头报告，受邀担任期刊Polymers客座编辑，中国化工学会会员。先后参与或主持了国家自然科学基金面上项目、“南太湖精英计划”项目、南京林业大学优秀博士学位论文创新基金、博士创新站项目等课题，并获“双一流”学科建设项目（PNFD）、江苏省优势学科项目（PAPD）及南京林业大学校长特别奖学金博士生奖学金等资助和奖励。
代表论文
[1] Wenbo Ye, Huazhong Ma, Liang Liu, Juan Yu, Jiangli Lai, Yaowei Fang*, Yimin Fan*. Biocatalyzed route for the preparation of surface-deacetylated chitin nanofibers. Green Chemistry, 2019, 21(11), 3143−3151.
[2] Wenbo Ye, Yanlei Hu, Huazhong Ma, Liang Liu, Juan Yu, Yimin Fan*. Comparison of cast films and hydrogels based on chitin nanofibers prepared using TEMPO/NaBr/NaClO and TEMPO/NaClO/NaClO2 systems. Carbohydrate Polymers, 2020, 237, 116125.
[3] Wenbo Ye, Liang Liu, Zhiguo Wang, Juan Yu, Yimin Fan*. Investigation of pretreatment methods for improving TEMPO-mediated oxidation and nanofibrillation efficiency of α-chitin. ACS Sustainable Chemistry & Engineering, 2019, 7(24), 19463−19473.
[4] Wenbo Ye, Fangtao Zhu, Yue Cai, Longyu Wang, Guangliang Zhang, Guangkuo Zhao, Xiaohe Chu, Qi Shuai, and Yunfeng Yan*. Improved paclitaxel delivery with PEG-b-PLA/zein nanoparticles prepared via flash nanoprecipitation. International Journal of Biological Macromolecules, 2022,221, 486−495.
[5] Wenbo Ye, Shingo Yokota, Yimin Fan*, Tetsuo Kondo*. A combination of aqueous counter collision and TEMPO-mediated oxidation for doubled carboxyl contents of α-chitin nanofibers. Cellulose, 2021, 28(4), 2167−2181.
[6] Wenbo Ye, Liang Liu, Juan Yu, Shilin Liu, Qiang Yong, Yimin Fan*. Hypolipidemic activities of partially deacetylated α-chitin nanofibers/nanowhiskers in mice. Food & Nutrition Research, 2018, 62, 1295−1303.
[7] Wenbo Ye, Guangliang Zhang, Xiaomin Liu, Qidi Ren, Fangqian Huang, Yunfeng Yan*. Fabrication of polysaccharide-stabilized zein nanoparticles by flash nanoprecipitation for doxorubicin sustained release. Journal of Drug Delivery Science and Technology, 2022, 70, 103183.
[8] Jie Jiang, Wenbo Ye, Liang Liu, Zhiguo Wang, Yimin Fan*, Tsuguyuki Saito, Akira Isogai*. Cellulose Nanofibers Prepared Using the TEMPO/Laccase/O2 System. Biomacromolecules, 2016, 18(1), 288−294.
[9] Jie Jiang, Wenbo Ye, Juan Yu, Yimin Fan*, Yuko Ono, Tsuguyuki Saito, Akira Isogai*. Chitin nanocrystals prepared by oxidation of α-chitin using the O2/laccase/TEMPO system. Carbohydrate Polymers, 2018, 189, 178–183.
[10] Wen Zhang, Wenbo Ye, Yunfeng Yan*. Advances in Photocrosslinkable Materials for 3D Bioprinting. Advanced Engineering Materials, 2021, 24, 2100663.
[11] Wen Zhang, Wenbo Ye, Yajun Wang, Yunfeng Yan*, Microfluidic fabrication of tunable alginate-based microfibers for the stable immobilization of enzymes. Biotechnology Journal,2022, 2200098.http://doi.org/10.1002/biot.202200098.
[12] Junhua Xu, Liang Liu, Juan Yu, Yujun Zou, Wenhui Pei, Lili Zhang, Wenbo Ye, Long Bai, Zhiguo Wang*, Yimin Fan*, Qiang Yong, Orlando J Rojas. Simple synthesis of self-assembled nacre-like materials with 3D periodic layers from nanochitin via hydrogelation and mineralization. Green Chemistry, 2022,24, 1308−1317.
[13] Liang Liu, Hechan Lv, Jie Jiang, Ke Zheng, Wenbo Ye, Zhiguo Wang, Yimin Fan*. Reinforced chitosan beads by chitin nanofibers for the immobilization of β-glucosidase. RSC Advances, 2015, 5(113), 93331−93336.
[14] Yangye Geng, Zhen Zhu*, Yingying Wang, Yiyun Wang, Shuiping Ouyang, Ke Zheng, Wenbo Ye, Yimin Fan, Zixin Wang, Dejing Pan. Multiplexing microelectrodes for dielectrophoretic manipulation and electrical impedance measurement of single particles and cells in a microfluidic device. Electrophoresis, 2019, 40(10), 1436−1445.
[15] Yunfeng Yan*, Guangliang Zhang, Chengfan Wu, Qidi Ren, Xiaomin Liu, Fangqian Huang, Yi Cao, and Wenbo Ye, Structural exploration of polycationic nanoparticles for siRNA delivery. ACS Biomaterials Science & Engineering,2022, 8(5), 1964–1974.
[16] Yunfeng Yan, Fangtao Zhu, Xiaomin Liu, Qidi Ren, Fangqian Huang, Wenbo Ye, Mengdan Zhao; Yunchun Zhao; Junpeng Zhao*, Shuai Qi*. Construction of degradable and amphiphilic triblock polymer carriers for effective delivery of siRNA. Macromolecular Bioscience, 2022, 2200232.
专利成果
[1] 范一民，叶文博，俞娟，王志国；高羧基含量几丁质纳米纤维分散液的制备方法、高羧基含量几丁质纳米纤维分散液和应用（ZL201810722441.0）
[2] 范一民，蒋杰，刘亮，叶文博，郑可，王志国；一种制备纤维素纳米纤维的方法（ZL201510274322.X）
[3] 具有减肥降脂作用的几丁质纳米纤维组合物及其应用；发明人：范一民，叶文博，俞娟，王志国
[4] 几丁质脱乙酰酶、几丁质纳米纤维分散液及其制备方法和应用；发明人：范一民，叶文博，俞娟，王志国（CN108795911A）
[5] 一种制备氧化甲壳素纳米纤维分散液的方法；发明人：范一民，蒋杰，叶文博，刘亮，郑可，王志国
[6] 一种紫杉醇纳米制剂及其制备方法和应用；发明人：燕云峰，叶文博，帅棋（CN114983976A）
面向生命健康重大需求，致力于生物医药先进制造技术创新和高端人才培养，重点开展绿色制药、新药创制和现代制剂技术的研发，目标解决高价值药物制造过程中的技术难题。课题组长期招聘博士后及科研助理，具备化工、合成、催化、生物材料、药物制剂等方向相关经验者优先考虑。有意向者请发送简历及代表论文至wenboye@zjut.edu.cn，诚挚欢迎您的加入！
